Abstract
Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-γ1 (PLC-γ1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-γ1 was highly enhanced in the regenerated nerves.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Kim, S., Shin, H., Eom, D. et al. Enhanced expression of neuronal nitric oxide synthase and phospholipase C-γ1 in regenerating murine neuronal cells by pulsed electromagnetic field. Exp Mol Med 34, 53–59 (2002). https://doi.org/10.1038/emm.2002.8
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DOI: https://doi.org/10.1038/emm.2002.8
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