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  • RESEARCH HIGHLIGHT

Non-antibiotic drug network reveals new leads for antibiotics

  1. Alex Eccleston
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Many non-antibiotic drugs are known to disrupt the human microbiome but their mechanisms of toxicity are unclear. Writing in Science, Guillen et al. use high-throughput genetic screens and network analysis to investigate how nearly 100 non-antibiotics inhibit bacterial growth. They uncover toxicity mechanisms that differ from conventional antibiotics, therefore implicating novel drug targets and leads for antibiotic development. The analysis also highlights how non-antibiotics could promote resistance to antibiotics.

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doi: https://doi.org/10.1038/d41573-024-00062-y

References

  1. Guillen, M. N. et al. Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics. Science 384, 93–100 (2024)

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