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Making macrophages with anti-tumour activity

  1. Sarah Crunkhorn
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Macrophages are one of the most abundant immune cells in the tumour microenvironment, contributing to cancer cell dissemination, immune evasion and metastatic outgrowth. However, they have also been reported to coordinate tumour-specific immune responses. For example, a number of studies have suggested that Kupffer cells (KCs), the resident macrophages of the liver, represent an innate immune barrier against tumour progression, but the mechanisms involved remain unknown.

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Nature Reviews Drug Discovery 23, 253 (2024)

doi: https://doi.org/10.1038/d41573-024-00045-z

References

  1. Deng, Z. et al. The nuclear factor ID3 endows macrophages with a potent anti-tumour activity. Nature https://doi.org/10.1038/s41586-023-06950-4 (2024)

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