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  • RESEARCH HIGHLIGHT

Expanding the gene editing landscape

  1. Sarah Crunkhorn
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Despite significant advances in genome-editing technologies, many pathogenic genetic variants are challenging to correct efficiently. Writing in Nature, Liu and colleagues now describe a novel genome-editing technology that directly mediates targeted insertions, deletions and point mutations in human cells, without requiring double-strand breaks (DSBs).

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Nature Reviews Drug Discovery 18, 904 (2019)

doi: https://doi.org/10.1038/d41573-019-00178-6

References

  1. Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature https://doi.org/10.1038/s41586-019-1711-4 (2019)

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