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Multifaceted roles of TRIM38 in innate immune and inflammatory responses

Cellular & Molecular Immunology volume 14, pages 331–338 (2017)Cite this article

Abstract

The tripartite motif-containing (TRIM) proteins represent the largest E3 ubiquitin ligase family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been intensively investigated in recent years. TRIM38 is essential for cytosolic RNA or DNA sensor-mediated innate immune responses to both RNA and DNA viruses, while negatively regulating TLR3/4- and TNF/IL-1β-triggered inflammatory responses. In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymatic activity-independent regulator. This review summarizes recent advances that highlight the critical roles of TRIM38 in the regulation of proper innate immune and inflammatory responses.

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Acknowledgements

We thank members of the Shu laboratory for helpful discussions. The work in the authors’ laboratory is supported by grants from the Ministry of Science and Technology of China (2016YFA0502102, 2014CB910103), the National Natural Science Foundation of China (3163000013, 31521091, and 91429304) and National Postdoctoral Program for Innovative Talents (BX201600116).

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  1. Medical Research Institute, Collaborative Innovation Center for Viral Immunology, School of Medicine, Wuhan University, Wuhan, 430071, China

    Ming-Ming Hu & Hong-Bing Shu

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  1. Ming-Ming Hu
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Correspondence to Hong-Bing Shu.

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Hu, MM., Shu, HB. Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol 14, 331–338 (2017). https://doi.org/10.1038/cmi.2016.66

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