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Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins

Cellular & Molecular Immunology volume 14, pages 237–244 (2017)Cite this article

Abstract

To successfully infect host cells and evade the host immune response, a type III secretion system (T3SS) is commonly used by enteric bacterial pathogens such as enteropathogenic Escherichia coli (EPEC). Recent findings have revealed that various effectors are injected into host cells through the T3SS and exert an inhibitory effect on inflammatory signaling pathways, subverting the immune responses to these pathogens. Here we review recent studies aimed at addressing the modulation of several important inflammatory signaling pathways modulated by EPEC effector proteins, such as the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, which provides insight into the unfinished work in this unexplored field and helps to identify novel positions in inflammatory signaling networks for EPEC effectors.

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Acknowledgements

This work was sponsored by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and Shanghai Pujiang Program.

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  1. Xiaonan Zhuang and Zijuan Chen: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China

    Xiaonan Zhuang, Zijuan Chen, Ruixue Zhou & Dapeng Yan

  2. Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai, 200092, China

    Chenxi He, Lin Wang & Baoxue Ge

  3. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200092, China

    Baoxue Ge

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  1. Xiaonan Zhuang
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Zhuang, X., Chen, Z., He, C. et al. Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins. Cell Mol Immunol 14, 237–244 (2017). https://doi.org/10.1038/cmi.2016.52

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