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SHP gains citizenship of the AMPK kingdom

Cellular & Molecular Immunology volume 8, pages 450–452 (2011)Cite this article

Various cytokines and chemokines are produced as a result of signaling through innate immune receptors. Such signaling is initiated by host–pathogen interactions in which the host's germline-encoded pattern recognition receptors, including Toll-like receptors (TLRs), recognize conserved microbial structures termed pathogen-associated molecular patterns.

TLRs are broadly distributed in immune cells and are responsible for eliciting innate responses and enhancing adaptive immunity to pathogens. The 12 members of the TLR family in mammals are characterized by an extracelluar leucine-rich repeat domain and an intracellular Toll/IL-1 receptor domain.

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References

  1. Kumar H, Kawai T, Akira S . Pathogen recognition by the innate immune system. Int Rev Immunol 2011; 30: 16–34.

    Article  CAS  Google Scholar 

  2. Liew FY, Xu D, Brint EK, O'Neil LA . Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5: 446–455.

    Article  CAS  Google Scholar 

  3. Yuk JM, Shin DM, Lee HM, Kim JJ, Kim SW, Jin HS et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol 2011; 12: 742–751.

    Article  CAS  Google Scholar 

  4. Liu XM, Peyton KJ, Shebib AR, Wang H, Korthuis RJ, Durante W . Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. Am J Physiol Heart Circ Physiol 2011; 300: H84–H93.

    Article  CAS  Google Scholar 

  5. Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S . Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol 2010; 80: 1895–1903.

    Article  CAS  Google Scholar 

  6. Zhang BB, Zhou G, Li C . AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009; 9: 407–416.

    Article  Google Scholar 

  7. Koenner AC, Bruening JC . Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol Metabol 2010; 22: 16–23.

    Article  Google Scholar 

  8. Salminen A, Hyttinen JM, Kaarmiranta KJ . AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. Mol Med 2011; 89: 667–676.

    Article  CAS  Google Scholar 

  9. Canto C, Auwerx J . AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010; 67: 3407–3423.

    Article  CAS  Google Scholar 

Download references

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  1. School of Biological Sciences, University of Ulsan, Meta-Inflammation Basic Research Laboratory, Ulsan, Korea

    Hun-Taeg Chung

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  1. Hun-Taeg Chung
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Correspondence to Hun-Taeg Chung.

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Chung, HT. SHP gains citizenship of the AMPK kingdom. Cell Mol Immunol 8, 450–452 (2011). https://doi.org/10.1038/cmi.2011.39

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