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HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration

Cellular & Molecular Immunology volume 6, pages 303–307 (2009)Cite this article

Abstract

To research whether specific alleles HLA class I (HLA-A and HLA-B) and class II (HLA-DR) are risk factors for the development of exudative type of Age Related Macular Degeneration (ARMD), HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascularization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD (p < 0.0113). However, we didn't find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.

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Authors and Affiliations

  1. Hospital Universitario Reina Sofia, Cordoba, Spain

    Enrique Villegas Becerril, Rafael González Fernández, Luis Pérula Torres, Manuel Santos Lacomba & José María Gallardo Galera

  2. Faculty of Medicine, University of Córdoba, Spain

    Manuel Santos Lacomba

Authors
  1. Enrique Villegas Becerril
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  2. Rafael González Fernández
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  3. Luis Pérula Torres
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  4. Manuel Santos Lacomba
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  5. José María Gallardo Galera
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Correspondence to Enrique Villegas Becerril.

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Becerril, E., Fernández, R., Torres, L. et al. HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration. Cell Mol Immunol 6, 303–307 (2009). https://doi.org/10.1038/cmi.2009.40

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  • DOI: https://doi.org/10.1038/cmi.2009.40

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