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Aplastic Anemia

Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT

Bone Marrow Transplantation volume 45, pages 1008–1013 (2010)Cite this article

Abstract

Graft rejection, with persistent pancytopenia, is well documented after allogeneic BMT (hematopoietic SCT (HSCT)) for severe aplastic anemia (SAA) and the prognosis is poor. The recovery of host-hematopoiesis, autologous recovery (AR), after allogeneic HSCT is a rare event and the incidence and long-term survival are unknown. We report a retrospective analysis of consecutive patients in the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT–WPSAA) registry between 1973 and 2005. A total of 45 cases of AR, of 1205 patients transplanted for SAA in 57 centers are reported. We describe characteristics and long-term outcome of patients with AR, compared with SAA patients from participating transplant centers without AR (n=1024) and patients with graft rejection (n=136) without autologous recovery. The estimated cumulative incidence of AR was 4.2% (3.1–5.6) (confidence interval (CI) 95%) with an OS of 84% (95% CI 83–107%). The OS of the control group was 74% (81–90) at 10 years of follow up, whereas the patients with graft failure had an OS of 16% (CI 12–28%). This retrospective analysis establishes the incidence and long-term survival of patients experiencing AR after allogeneic HSCT for SAA.

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Acknowledgements

We thank the following EBMT centers and physicians involved in this study: Basel#202 (Andrè Tichelli), Belfast#268 (Frank Jones), Dublin#257 (Shaun Mc Cann), Florence#304 (Stefano Guidi), Freiburg#810 (Duffner Ulrich), Gdansk#799 (Andrzej Hellmann), Genova#274 (Sandro Dallorso), Hamburg#614 (Peter Mundhenk), Idar Oberstein#592 (Ludwig Kraut), Leiden#203 (Elisabeth Korthof), Lisboa#300 (Manuel Abecasis), London#539 (Judith Marsh), Lublin#678 (Kowalczyk Jerzy), Lyon#671 (Nicole Raus), Manchester#521 (Andrew Will), Milan#265 (Aldo Della Volpe), Monza#279 (Cornelio Uderzo), Padova #285 (Simone Cesaro), Paris#222 (Rio Bernard), Paris#631 (Dalle Jean-Huges), Pavia#286 (E.Paolo Alessandrino), Pavia#557 (Franco Locatelli), Sheffield#778 (Ajay Vora), Ulm#204 (Hubert Schrezenmeier), Wroclaw#538 (Krzysztof Suchnicki) and Geneva#561 (Jakob Passweg).

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Authors and Affiliations

  1. Haematology Department, St James's Hospital, Trinity College Dublin, Dublin, Ireland

    A Piccin, S McCann, E Hand & M Lawler

  2. Department of Haematology, Ospedale San Maurizio, Bolzano, Italy

    A Piccin

  3. Department of Haematology, Hôpital Saint Louis, Paris, France

    G Socié

  4. Department of Haematology, Ospedale San Martino, Genoa, Italy

    R Oneto & A Bacigalupo

  5. Haematology and SCT Unit, Ospedale San Camillo, Rome, Italy

    A Locasciulli

  6. Department of Haematological Medicine, St George's Hospital, London, UK

    J Marsh

  7. Universitätsklinikum Ulm, Institute Fur Klimische Transfusions Medzin Ulm, Ulm, Germany

    H Schrezenmeier

  8. Department of Haematology, University Hospital Basel, Basel, Switzerland

    A Tichelli

  9. Department de Medecine Interne, Hospitaux Universitaires de Geneve, Geneva, Switzerland

    J Passweg

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  1. A Piccin
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  2. S McCann
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  3. G Socié
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  11. M Lawler
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on behalf of the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (WPSAA, EBMT)

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Correspondence to S McCann.

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Piccin, A., McCann, S., Socié, G. et al. Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT. Bone Marrow Transplant 45, 1008–1013 (2010). https://doi.org/10.1038/bmt.2009.296

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