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Donor cell-derived sarcoidosis after allogeneic BMT

Bone Marrow Transplantation volume 43, pages 507–508 (2009)Cite this article

A 55-year-old Japanese woman had suffered from follicular lymphoma since June 2005. Although she had undergone several chemotherapies with rituximab and had achieved CR in March 2006, she relapsed in June 2006. She achieved CR again with salvage chemotherapy. On account of her follicular lymphoma the international prognostic index was in the high-risk group, we decided to perform allogeneic haematopoietic SCT (HSCT). As she did not have any suitable sibling donors, we selected an unrelated woman donor who had one locus mismatch HLA phenotype and genotype (DRB1 locus).

In April 2007, she received allogeneic BMT after a reduced-intensity conditioning regimen consisting of TBI (4 Gy/2fr), fludarabine (30 mg/m2/day for 6 days) and intravenous BU (0.8 mg/kg × 4/day for 2 days). Acute GVHD prophylaxis consisted of MTX (15 mg/m2 on day 1, 10 mg/m2 on days 3 and 6) and tacrolimus (0.025 mg/kg). Engraftment was achieved on day 17 after BMT, confirmed by complete donor type chimerism using short tandem repeat-based PCR assay. We verified her CR state by BM biopsy, computer tomography imaging and fluorodeoxyglucose positron emission tomography (FDG-PET) imaging after BMT. After engraftment she did not have any complications or acute GVHD, and she was discharged from our hospital on day 66 after BMT.

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Authors and Affiliations

  1. Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    R Morita, S Hashino, M Onozawa, K Kahata, T Kondo & M Asaka

  2. Division of Pathology, Hokkaido University Hospital, Sapporo, Japan

    K Kubota & Y Matsuno

  3. Division of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan

    S Suzuki

  4. Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    M Imamura

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  1. R Morita
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  2. S Hashino
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  3. K Kubota
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  5. K Kahata
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  6. T Kondo
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  7. S Suzuki
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  8. Y Matsuno
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  9. M Imamura
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  10. M Asaka
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Correspondence to R Morita.

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Morita, R., Hashino, S., Kubota, K. et al. Donor cell-derived sarcoidosis after allogeneic BMT. Bone Marrow Transplant 43, 507–508 (2009). https://doi.org/10.1038/bmt.2008.340

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