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Allografting

Successful outcome of allo-SCT in high-risk pediatric AML using chemotherapy-only conditioning and post transplant immunotherapy

Bone Marrow Transplantation volume 42, pages 253–257 (2008)Cite this article

A Corrigendum to this article was published on 12 November 2008

Abstract

We report successful outcome in 13 children (median age 2.2 years) with high-risk AML who received SCT from an unrelated (11) or identical sibling (2) donor after a preparative regimen consisting of BU, CY and melphalan. Three children were ‘poor’-risk in first CR, three in the second CR, five in PR and two had resistant disease. Immunotherapeutic strategies were employed to maximize a GVL response escalating through a reduced dose of alemtuzumab, early taper of CsA, donor lymphocyte infusion and treatment with α-IFN. Ten out of 13 (77%) children are alive in CR at a median of 41 months (range: 17–88) from SCT. There was no TRM, but three children relapsed and died 3, 4 and 17 months after SCT. These encouraging early results warrant further studies in children with very high-risk AML.

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Authors and Affiliations

  1. Bone Marrow Transplant Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK

    S Bonnanomi, P Connor, P Amrolia, K Rao, N Goulden & P Veys

  2. Department of Haematology, Great Ormond Street Hospital for Children NHS Trust, London, UK

    D Webb, P Ancliff & N Goulden

  3. Clinical Transplantation Laboratory, Royal London Hospital, London, UK

    D McCloskey & S Hemmatpour

Authors
  1. S Bonnanomi
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  2. P Connor
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  3. D Webb
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  4. P Ancliff
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  5. P Amrolia
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  6. K Rao
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  7. D McCloskey
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  8. S Hemmatpour
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  9. N Goulden
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  10. P Veys
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Correspondence to P Veys.

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Bonnanomi, S., Connor, P., Webb, D. et al. Successful outcome of allo-SCT in high-risk pediatric AML using chemotherapy-only conditioning and post transplant immunotherapy. Bone Marrow Transplant 42, 253–257 (2008). https://doi.org/10.1038/bmt.2008.160

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  • DOI: https://doi.org/10.1038/bmt.2008.160

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