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Stem cells: the challenge and opportunities

Bone Marrow Transplantation volume 42, pages S57–S59 (2008)Cite this article

Abstract

Recent studies have clearly identified that hematopoietic stem cells (HSC) are part of a hierarchical organization defined by cells able to initiate long-term repopulation (LT-HSC) of injured BM followed by populations with transient repopulation ability. As HSCs are able to supply blood cells for the lifespan of the individual, LT-HSCs undergo an aging process. The consequences of aging are an increase in the stem cell pool size, increased self-renewal and production of cells with expression of myeloid-specific genes and genes commonly expressed in myeloid leukemia. The age-related increased incidence of myeloproliferative disorders is therefore not surprising. Marrow cells circulate and migrate to a number of different organs. Previously assumed tissue and organ specificities appear to be less stringent and primitive cells residing in one organ may contribute to the structural and functional regeneration of other organs. It is intriguing to speculate that cells and cytokines used in appropriate concentrations may be able to repair damaged organs by using the defective organ as a scaffold, thus reducing the need for the transplantation of solid organs.

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References

  1. Till JE, McCulloch EA . A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Research 1961; 14: 213–222.

    Article  CAS  Google Scholar 

  2. Rossi DJ, Bryder D, Weissman IL . Hematopoietic stem cell aging: mechanism and consequence. Exp Gerontol 2007; 42: 385–390.

    Article  CAS  Google Scholar 

  3. Manfredini R, Zini R, Salati S, Siena M, Tenedini E, Tagliafico E et al. The kinetic status of hematopoietic stem cell subpopulations underlies a differential expression of genes involved in self-renewal, commitment, and engraftment. Stem Cells 2005; 23: 496–506.

    Article  CAS  Google Scholar 

  4. Kamminga LM, De Hann G . Cellular memory and hematopoietic stem cell aging. Stem Cells Aging 2006; 24: 1143–1149.

    Article  CAS  Google Scholar 

  5. Lapidot T, Kollet O . The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 2002; 16: 1992–2003.

    Article  CAS  Google Scholar 

  6. Dar A, Kollet O, Lapidot T . Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Exp Hematol 2006; 34: 967–975.

    Article  CAS  Google Scholar 

  7. Nilsson SK, Simmons PJ, Bertoncello I . Hemopoietic stem cell engraftment. Exp Hematol 2006; 34: 123–129.

    Article  CAS  Google Scholar 

  8. Dar A, Kollet O, Lapidot T . Mutual reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Exp Hematol 2006; 34: 967–975.

    Article  CAS  Google Scholar 

  9. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005; 23: 879–894.

    Article  CAS  Google Scholar 

  10. Shi M, Li J, Liao L, Chen B, Li B, Chen L et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica 2007; 92: 897–904.

    Article  Google Scholar 

  11. Lang D, Powell SK, Plummer RS, Young KP, Ruggeri BA . PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol 2007; 73: 1–14.

    Article  CAS  Google Scholar 

  12. Souabni A, Jochum W, Busslinger M . Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood 2007; 109: 281–289.

    Article  CAS  Google Scholar 

  13. Retz MM, Sidhu SS, Blaveri E, Kerr SC, Dolganov GM, Lehmann J et al. CXCR4 expression reflects tumor progression and regulates motility of bladder cancer cells. Int J Cancer 2005; 114: 182–189.

    Article  CAS  Google Scholar 

  14. Zhang L, Yeger H, Das B, Irwin MS, Baruchel S . Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma. Neoplasia 2007; 9: 36–46.

    Article  CAS  Google Scholar 

  15. Jones J, Marian D, Weich E, Engl T, Wedel S, Relja B et al. CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells. Exp Cell Res 2007; 313: 4051–4065.

    Article  CAS  Google Scholar 

  16. Furuya M, Suyama T, Usuri H, Kasuya Y, Nishiyama M, Tanaka N et al. Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis. Hum Pathol 2007; 38: 1676–1687.

    Article  CAS  Google Scholar 

  17. Petit I, Jin D, Rafii S . The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 2007; 28: 299–307.

    Article  CAS  Google Scholar 

  18. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L et al. Liver from bone marrow in humans. Hepatology 2000; 32: 11–16.

    Article  CAS  Google Scholar 

  19. Schwartz RS, Curfman GD . Can the heart repair itself? N Engl J Med 2002; 346: 2–4.

    Article  Google Scholar 

  20. Shingo T, Sorokan ST, Shimazaki T, Weiss S . Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001; 21: 9733–9743.

    Article  CAS  Google Scholar 

  21. Kolb B, Morshead C, Gonzalez C, Kim M, Gregg C, Shingo T et al. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. J Cereb Blood Flow & Metabolism 2007; 27: 983–997.

    Article  CAS  Google Scholar 

Download references

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  1. Department of Medical Oncology/Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada

    H A Messner

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  1. H A Messner
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Correspondence to H A Messner.

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Messner, H. Stem cells: the challenge and opportunities. Bone Marrow Transplant 42 (Suppl 1), S57–S59 (2008). https://doi.org/10.1038/bmt.2008.116

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