Abstract
Female transgenic mice lacking a functional c-mos proto-oncogene develop ovarian teratomas, indicating that c-mos may behave as a tumour-suppressor gene for this type of tumour. We have analysed the entire coding region of the c-MOS gene in a series of human ovarian teratomas to determine whether there are any cancer-causing alterations. DNA from twenty teratomas was analysed by single-strand conformational analysis (SSCA) and heteroduplex analysis (HA) to screen for somatic and germline mutations. In nine of these tumours the entire gene was also sequenced. A previously reported polymorphism and a single new sequence variant were identified, neither of which we would predict to be disease-causing alterations. These results suggest that mutations in the coding region of the c-MOS gene do not play a significant role in the genesis of human ovarian teratomas.
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de Foy, K., Gayther, S., Colledge, W. et al. Mutation analysis of the c-mos proto-oncogene in human ovarian teratomas. Br J Cancer 77, 1642–1644 (1998). https://doi.org/10.1038/bjc.1998.269
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DOI: https://doi.org/10.1038/bjc.1998.269
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