Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical Oncology
  • Published:

Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis – JCOG study 9413

British Journal of Cancer volume 76, pages 90–92 (1997)Cite this article

Abstract

Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 16 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vomiting on day 1, and 16 (48%) achieved total control on days 1-5 with acceptable toxicity. High-dose dexamethasone for cisplatin-induced delayed emesis should be further evaluated in a phase III trial.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa-city, Chiba, Japan

    I Sekine

Authors
  1. I Sekine
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y Nishiwaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Kakinuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K Kubota
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F Hojo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H Ohmatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M Yokozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. K Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T Miyamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J Takafuji
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. T Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sekine, I., Nishiwaki, Y., Kakinuma, R. et al. Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced emesis – JCOG study 9413. Br J Cancer 76, 90–92 (1997). https://doi.org/10.1038/bjc.1997.341

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/bjc.1997.341

This article is cited by

Search

Advanced search

Quick links