Abstract
The polymerase chain reaction has been used to determine the presence of human papillomavirus (HPV) 16 and HPV 18 DNA sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. The detection of HPV 16 or HPV 18 DNA sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression.
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Woodman, C., Rollason, T., Ellis, J. et al. Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix. Br J Cancer 73, 553–556 (1996). https://doi.org/10.1038/bjc.1996.96
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DOI: https://doi.org/10.1038/bjc.1996.96