Abstract
Tallimustine is a novel benzoyl mustard derivative from distamycin A with a unique mode of action. It is a DNA minor groove binder and produces highly sequence-specific alkylations. Previous studies have shown significant anti-tumour effects in animal models. We performed a phase II study in previously untreated patients with advanced colorectal cancer, using a schedule of i.v. bolus infusions of 900 microgram m-2 once every 4 weeks. Seventeen patients were enrolled, and no responses were documented in 14 evaluable patients. Toxicity mainly consisted a highly selective neutropenia, which warrants further investigation of this agent in combination with myeloid growth factors.
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Punt, C., Humblet, Y., Roca, E. et al. Tallimustine in advanced previously untreated colorectal cancer, a phase II study. Br J Cancer 73, 803–804 (1996). https://doi.org/10.1038/bjc.1996.140
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DOI: https://doi.org/10.1038/bjc.1996.140