Abstract
Fifty-seven patients with metastatic melanoma were treated with interleukin 2 (IL-2) 7.8 MIU m-2 day-1 as a continuous infusion for 4 days combined with interferon alpha (IFN-alpha) 6 MIU m-2 day-1 subcutaneously on days 1 and 4. The cycle was repeated every 2 weeks for a maximum number of 13 cycles. Of the 51 evaluable patients, one (2%) achieved a complete and seven (14%) a partial response (total response rate 16%; CI 7-29%). Median time to progression and median survival were 2.5 and 11.3 months respectively. This regimen of IL-2 and IFN-alpha appeared to be only moderately active.
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Kruit, W., Goey, S., Calabresi, F. et al. Final report of a phase II study of interleukin 2 and interferon α in patients with metastatic melanoma. Br J Cancer 71, 1319–1321 (1995). https://doi.org/10.1038/bjc.1995.256
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DOI: https://doi.org/10.1038/bjc.1995.256