Abstract
Nuclear deoxyribonucleic acid (DNA) content of hepatocellular carcinoma (HCC) in 41 South African and 47 Japanese patients at autopsy was analysed by dual-wavelength microspectrophotometry. The DNA distribution patterns were classified as type I, II, III or IV and as low ploidy (types I, II) or high ploidy (types III, IV), according to the degree of dispersion. We found a significantly higher incidence of high ploidy in South African HCC than in Japanese HCC. Moreover, type IV was significantly more frequent among South Africans than among the Japanese. These findings demonstrate that large differences in biological characteristics and clinical behaviour of HCC between South Africa and Japan may reflect differences in DNA distribution patterns which we observed between these two races.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoshida, Y., Kanematsu, T., Matsumata, T. et al. A comparative study on hepatocellular carcinoma between South Africans and Japanese from the viewpoint of nuclear DNA content. Br J Cancer 69, 362–366 (1994). https://doi.org/10.1038/bjc.1994.66
Issue Date:
DOI: https://doi.org/10.1038/bjc.1994.66
This article is cited by
-
Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV
BMC Gastroenterology (2020)