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  • Experimental Oncology
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Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517)

British Journal of Cancer volume 68, pages 916–919 (1993)Cite this article

Abstract

Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating.

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Authors and Affiliations

  1. Oncology Department, Farmitalia Carlo Erba, Research Center, Nerviano, Milano, Italy

    L Capolongo

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  1. L Capolongo
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  2. G Melegaro
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  3. M Broggini
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  4. N Mongelli
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  5. M Grandi
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Capolongo, L., Melegaro, G., Broggini, M. et al. Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). Br J Cancer 68, 916–919 (1993). https://doi.org/10.1038/bjc.1993.454

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  • DOI: https://doi.org/10.1038/bjc.1993.454

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