Abstract
Antimetabolites are S-phase specific anticancer drugs. Administration of bromodeoxyuridine (BrdUrd) to tumour bearing mice was followed by treatment with cytosine arabinoside or hydroxyurea. Anti-BrdUrd immunocytochemistry visualised susceptible tumour and intestinal crypt cells at electron microscope level, showing unequivocally that cells that were in S-phase at the time of administration of the drugs subsequently died by apoptosis.
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Sarraf, C., Ansari, T., Conway, P. et al. Bromodeoxyuridine-labelled apoptosis after treatment with antimetabolites in two murine tumours and in small intestinal crypts. Br J Cancer 68, 678–680 (1993). https://doi.org/10.1038/bjc.1993.408
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DOI: https://doi.org/10.1038/bjc.1993.408
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