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  • Clinical Oncology/Epidemiology
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Clinical Oncology/Epidemiology

Analysis by DNA polymerase α activity of human breast tumour proliferation and the effect of endocrine therapy

British Journal of Cancer volume 62, pages 263–266 (1990)Cite this article

Abstract

Cytosols of human breast tumours have been assayed for DNA dependent DNA polymerase alpha activity. DNA polymerase alpha activity in benign tumours was found to be significantly lower than in untreated malignant tumours. Biopsy samples removed surgically before and after endocrine therapy showed reduced DNA polymerase alpha activity in 6 out of 9 patients treated with 4-hydroxyandrostenedione, and in 6 out of 7 patients treated with MPA. DNA polymerase alpha activity in malignant breast tumours was higher in oestrogen receptor negative than oestrogen receptor positive tumours.

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Authors and Affiliations

  1. Department of Chemical Pathology, St Mary's Hospital Medical School, London, UK

    NG Coldham

Authors
  1. NG Coldham
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  2. LC Lai
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  3. MJ Reed
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  4. MW Ghilchik
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  5. NA Shaikh
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  6. VHT James
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Coldham, N., Lai, L., Reed, M. et al. Analysis by DNA polymerase α activity of human breast tumour proliferation and the effect of endocrine therapy. Br J Cancer 62, 263–266 (1990). https://doi.org/10.1038/bjc.1990.273

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  • DOI: https://doi.org/10.1038/bjc.1990.273

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