Abstract
The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour responsiveness to these drugs. A partial resistance was already acquired at the 2nd transplant generation. In contrast, a gradual decrease in therapeutic response was observed with 10 mg kg-1 cisplatin. Irradiation with a local dose of 10 Gy induced no resistance. The three induced drug-resistant sublines were characterized in terms of the time course of development of resistance, the degree of induced resistance, cross-resistance, growth rate and stability of the phenotype.
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Mattern, J., Bak, M., Hoever, K. et al. Development of drug resistance in a human epidermoid lung carcinoma xenograft line. Br J Cancer 58, 30–33 (1988). https://doi.org/10.1038/bjc.1988.155
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DOI: https://doi.org/10.1038/bjc.1988.155