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  • Experimental Oncology
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Expression of a Tn-like epitope by carcinoma cells

British Journal of Cancer volume 56, pages 734–737 (1987)Cite this article

Abstract

A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

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Authors and Affiliations

  1. Department of Haematology, Flinders University, Adelaide, South Australia

    DJ Roxby

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  1. DJ Roxby
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  2. JM Skinner
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  3. AA Morley
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  4. S Weeks
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  5. M Burpee
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Roxby, D., Skinner, J., Morley, A. et al. Expression of a Tn-like epitope by carcinoma cells. Br J Cancer 56, 734–737 (1987). https://doi.org/10.1038/bjc.1987.279

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  • DOI: https://doi.org/10.1038/bjc.1987.279

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