Abstract
This is the second report of a large case control study of lymphoma/leukaemia occurring in Yorkshire during 1979-84, and deals with chronic lymphocytic leukaemia presenting either in its haematological (CLL) or more solid lymphomatous (malignant lymphoma-lymphocytic or MLL) forms. In all, 330 cases and 561 controls were interviewed. The results support the concept that CLL/MLL is a condition of multiple aetiologies with evidence for genetic predisposition through an excess of family cases, immune perturbation demonstrated by excessive previous skin diseases and phenylbutazone use, and viral involvement shown by links with infectious diseases and multiple sclerosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Cartwright, R., Bernard, S., Bird, C. et al. Chronic lymphocytic leukaemia: case control epidemiological study in Yorkshire. Br J Cancer 56, 79–82 (1987). https://doi.org/10.1038/bjc.1987.158
Issue Date:
DOI: https://doi.org/10.1038/bjc.1987.158
This article is cited by
-
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
Nature Genetics (2010)
-
Familial chronic lymphocytic leukemia
Current Hematologic Malignancy Reports (2008)
-
Genetic susceptibility to chronic lymphocytic leukemia
Leukemia (2002)
-
Cancer mortality of family members of patients with chronic lymphocytic leukemia
European Journal of Epidemiology (1994)
-
Prior medical conditions and the risk of adult leukemia in Shanghai, People's Republic of China
Cancer Causes & Control (1993)