Abstract
6-keto-PGF1 alpha and thromboxane B2 were determined by radioimmunoassay in 37 extracts of breast carcinomata, 8 fibroadenomata, 12 sclerocystic-disease specimens and 51 normal breast tissues. More prostanoids were extracted from carcinomata than from normal specimens, fibroadenomata or sclerocystic-disease tissues (P less than 0.05). The 6-keto-PGF1 alpha/TXB2 ratio was higher in carcinomata than in normal tissues and fibroadenomata (P less than 0.05) but was not significantly different from the ratio in sclerocystic disease. The prostaglandin levels and the 6-keto-PGF1 alpha/TXB2 ratios from carcinomata did not correlate significantly with age, tumour size, differentiation, lymph node status, nuclear-cytoplasmic ratio, host cell reaction, mast cells, necrosis, elastosis, fibrosis or blood vessel density. Lower nuclear density was associated with lower 6-keto-PGF1 alpha/TXB2 ratios (P = 0.01) whereas the latter value was higher when infiltration was lower (P = 0.03). There was a positive correlation between mitotic index and the 6-keto-PGF1 alpha/TXB2 ratio (P = 0.04). Cumulation of variables revealed lower prostanoid ratios in tumours greater than 2 cm without lymph node metastasis then tumours less than 2 cm with lymph node metastasis (P = 0.04). A first follow-up (14 months) showed a higher 6-keto-PGF1 alpha/TXB2 ratio in patients who developed metastasis (P = 0.04). Our study does not confirm the hypothesis that high prostacyclin levels are a good prognostic index in breast cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Laekeman, G., Vergote, I., Keersmaekers, G. et al. Prostacyclin and thromboxane in benign and malignant breast tumours. Br J Cancer 54, 431–437 (1986). https://doi.org/10.1038/bjc.1986.194
Issue Date:
DOI: https://doi.org/10.1038/bjc.1986.194
This article is cited by
-
Differential effect of L -NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat
British Journal of Pharmacology (1997)
-
Relation of malignant tumor to prostacyclin and thromboxane
Chinese Journal of Cancer Research (1995)
-
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies
Cancer Chemotherapy and Pharmacology (1994)
-
Characterization of immortalized mouse granulosa cell lines
In Vitro Cellular & Developmental Biology - Animal (1993)
-
Clinical significance of prostacyclin and thromboxane in cancer of the female breast and genital tract
Cancer and Metastasis Reviews (1992)