Abstract
Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations contribute to the development of neoplastic disease. Experiments leading to the identification of cellular oncogenes are reviewed and our current understanding of the mechanisms by which they induce transformation of cells in culture and may contribute to the pathogenesis of neoplasms in vivo is discussed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional information
Delivered at the 25th Annual General Meeting of the British Association for Cancer Research, Manchester, April, 4, 1984.
Rights and permissions
About this article
Cite this article
Cooper, G. The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms. Br J Cancer 50, 137–142 (1984). https://doi.org/10.1038/bjc.1984.155
Issue Date:
DOI: https://doi.org/10.1038/bjc.1984.155
This article is cited by
-
Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors
Diseases of the Colon & Rectum (1992)
-
Expression of Genes in Cloned Murine Cell Lines that can be Maintained in Both Interleukin 2‐ and Interleukin 3‐Dependent Growth States
Immunology & Cell Biology (1987)
-
Evaluation of genetic radiation hazards in man: History, present status and perspectives
Journal of Genetics (1986)