Abstract
A highly hydrophobic alkylating agent, 1-N,N-bis(beta-bromoethyl) amino-3-methylnaphthalene, given as the free drug in oil, cured a substantial proportion of mice bearing the PC6 myeloma in the dose range 2-7 mg/kg. However, these doses were toxic, and the LD50 was 6-7 mg/kg. When incorporated in liposomes, similar curative effects were obtained at doses of 10-41 mg/kg without material toxicity, even at the highest dose. Liposome entrapment therefore greatly increases the therapeutic efficiency of this agent.
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Babbage, J., Berenbaum, M. Increased therapeutic efficiency of a lipid-soluble alkylating agent incorporated in liposomes. Br J Cancer 45, 830–834 (1982). https://doi.org/10.1038/bjc.1982.134
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DOI: https://doi.org/10.1038/bjc.1982.134