Abstract
A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described.
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Major, I. Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays. Br J Cancer 40, 903–913 (1979). https://doi.org/10.1038/bjc.1979.284
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DOI: https://doi.org/10.1038/bjc.1979.284
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