Abstract
The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 35% of membrane-bound RNA. The secretion of albumin, however, is inhibited. This inhibition of secretion is apparently the result of a change in membrane flow and differentiation, transfer of nascent protein from smooth-surfaced vesicles to the Golgi apparatus is blocked. The significance of these findings is discussed.
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Harson, M., Williams, D. Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene. Br J Cancer 40, 791–797 (1979). https://doi.org/10.1038/bjc.1979.262
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DOI: https://doi.org/10.1038/bjc.1979.262