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Serological aspects of rat tumour xenograft growth in athymic nude mice

Abstract

The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG.

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Pimm, M., Baldwin, R. Serological aspects of rat tumour xenograft growth in athymic nude mice. Br J Cancer 39, 116–121 (1979). https://doi.org/10.1038/bjc.1979.21

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  • DOI: https://doi.org/10.1038/bjc.1979.21

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