Abstract
The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.
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Steel, G., Adams, K. Enhancement by cytotoxic agents of artificial pulmonary metastasis. Br J Cancer 36, 653–658 (1977). https://doi.org/10.1038/bjc.1977.247
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DOI: https://doi.org/10.1038/bjc.1977.247
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