Abstract
Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.
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Shalet, S., Beardwell, C., Jones, P. et al. Ovarian failure following abdominal irradiation in childhood. Br J Cancer 33, 655–658 (1976). https://doi.org/10.1038/bjc.1976.103
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DOI: https://doi.org/10.1038/bjc.1976.103
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