Abstract
Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [3H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not.
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Creaven, P., Hansen, H., Alford, D. et al. Methotrexate in Liver and Bile after Intravenous Dosage in Man. Br J Cancer 28, 589–591 (1973). https://doi.org/10.1038/bjc.1973.190
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DOI: https://doi.org/10.1038/bjc.1973.190
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