Abstract
Aim:
The present study was designed to investigate the expression of Polo-like kinase 1 (PLK1) and survivin in non-Hodgkin's lymphoma (NHL).
Methods:
The expression of PLK1 and survivin were detected with immunohistochemical techniques.
Results:
The expression rate of PLK1 and survivin were 63.6% (56/88) and 79.5% (70/88) in NHL, respectively. PLK1 expression correlated with systemic symptoms, lactate dehydrogenase levels, and international prognostic index scores in B-NHL and T-NHL, while survivin did not.
Conclusion:
PLK1 and survivin are both overexpressed in NHL. There is a significant relationship between the overexpression of PLK1 and clinical features.
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Liu, L., Zhang, M. & Zou, P. Expression of PLK1 and survivin in non-Hodgkin's lymphoma treated with CHOP. Acta Pharmacol Sin 29, 371–375 (2008). https://doi.org/10.1111/j.1745-7254.2008.00750.x
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DOI: https://doi.org/10.1111/j.1745-7254.2008.00750.x
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