Abstract
Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I'd like to summarize the issue and discuss questions with pharmacological criteria.
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Project supported by the Korea Science and Engineering Foundation Grant (R01-2005-000-10011-02005).
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Im, Ds. Two ligands for a GPCR, proton vs lysolipid. Acta Pharmacol Sin 26, 1435–1441 (2005). https://doi.org/10.1111/j.1745-7254.2005.00237.x
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DOI: https://doi.org/10.1111/j.1745-7254.2005.00237.x
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