Abstract
Aim:
To explore the relationship between differential leucocyte count and coronary atherosclerosis.
Methods:
The study population consisted of 507 consecutive patients (376 male and 131 female) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' smoking and drinking habits were investigated, and anthropometric measurements, serum measurements, and hematological measurements were conducted for every patient. The severity of coronary atherosclerosis was defined by using Gensini's score system. One-way ANOVA, Spearman's correlation analysis, and multivariate stepwise linear regression analysis were employed to explore the relationship between differential leucocyte count and coronary atherosclerosis.
Results:
Oneway ANOVA indicated that the diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and platelet count differed among the groups according to Gensini's score, the tertile values of which were used as cutoff points. Spearman's correlation analysis suggested that Gensini's score was significantly correlated with age, diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and erythrocyte count, respectively. Multivariate stepwise linear regression analysis show that neutrophil count (β=0.247, P=0.000), age (β=0.141, P=0.001), glucose (β=0.173, P=0.000), creatinine (β=0.088, P=0.063), hemoglobin (β=-0.168, P=0.013) and sex (men were coded as 1 and women were coded as 2; β=-0.121, P=0.012) were significantly independently associated with the Gensini's score.
Conclusion:
The independent association of neutrophil count with the angiographical characteristics of coronary atherosclerosis, as estimated by Gensini's score, strongly suggests that granulocytosis may play a role in the development of coronary atherosclerosis.
Similar content being viewed by others
Article PDF
References
Danesh J, Collins R, Appleby P, Peto R . Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998; 279: 1477–82.
Madjid M, Awan I, Willerson JT, Casscells SW . Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 2004; 44: 1945–56.
Naruko T, Ueda M, Haze K, van der Wal AC, van der Loos CM, Akira Itoh A, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002; 106: 2894–900.
Gensini GG . A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983; 51: 606.
Judkins MP . A percutaneous transfemoral technique. Radiology 1967; 89: 815–21.
American Heart Association. Heart Disease and Stroke Statistics: 2003 Update. Dallas, Texas: American Heart Association; 2002.
Ross R . Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115–26.
Wheeler JG, Mussolino ME, Gillum RF, Danesh J . Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30,374 individuals. Eur Heart J 2004; 25: 1287–92.
Avanzas P, Arroyo-Espliguero R, Cosin-Sales J, Aldama G, Pizzi C, Quiles J, et al. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes. Heart 2004; 90: 847–52.
Jurkovitz CT, Abramson JL, Vaccarino LV, Weintraub WS, McClellan WM . Association of high serum creatinine and anemia increases the risk of coronary events: results from the prospective community-based atherosclerosis risk in communities (ARIC) study. J Am Soc Nephrol 2003; 14: 2919–25.
Arant CB, Wessel TR, Olson MB, BM CN, Sopko G, Rogers WJ, et al. Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation Study. J Am Coll Cardiol 2004; 43: 2009–14.
Sasso FC, Carbonara O, Nasti R, Campana B, Marfella R, Torella M, et al. Glucose metabolism and coronary heart disease in patients with normal glucose tolerance. JAMA 2004; 291: 1857–63.
Faxon DP, Creager MA, Smith SC Jr, Pasternak RC, Olin JW, Bettmann MA, et al. Atherosclerotic vascular disease conference. Executive summary: atherosclerotic vascular disease conference proceeding for healthcare professionals from a Special Writing Group of the American Heart Association. Circulation 2004; 109: 2595–604.
Author information
Authors and Affiliations
Corresponding author
Additional information
Project supported by the National Natural Science Foundation of China (No 30400173).
Rights and permissions
About this article
Cite this article
Jia, Ez., Yang, Zj., Yuan, B. et al. Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis. Acta Pharmacol Sin 26, 1057–1062 (2005). https://doi.org/10.1111/j.1745-7254.2005.00169.x
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1111/j.1745-7254.2005.00169.x