Abstract
Aim:
To demonstrate and compare hemodynamic phenotypes of blood pressure (BP), blood pressure variability (BPV) and baroreflex sensitivity (BRS) in genetic hypertensive rats.
Methods:
BP was recorded continuously in conscious, freely moving rats using a computerized technique. BPV was expressed as the standard deviation of beat-to-beat BP values during a 1-h period. BRS was determined by measuring the heart period prolongation in response to the elevation in BP produced by an intravenous injection of phenylephrine.
Results:
Body weight and heart period were not different between spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP) at the age of 15 weeks. The BP level was markedly higher in SHR-SP than SHR, whereas there were no significant differences in BPV and BRS. Quantitatively, systolic, diastolic and mean BP were significantly elevated by 36.9%, 42.9% and 39.5%, respectively, in SHR-SP compared with SHR (P < 0.01). However, their variabilities were elevated only by 14.0%, 0.4% and 10.1%, respectively, without statistical significance (P > 0.05).
Conclusion:
BPV and BRS were not changed in parallel with the BP alterations in SHR and SHR-SP.
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Project supported by the National Natural Science Foundation of China (No 30371649) and “Shu Guang” project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation (No 04SG37).
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Zhan, Ls., Guan, Yf., Su, Df. et al. Blood pressure variability and baroreflex sensitivity are not different in spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats. Acta Pharmacol Sin 26, 959–962 (2005). https://doi.org/10.1111/j.1745-7254.2005.00144.x
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DOI: https://doi.org/10.1111/j.1745-7254.2005.00144.x
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