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Biological monitoring of midwives' exposure to N2O using the Bio-VOC breath sampler

Abstract

The use of exhaled breath as a biological monitoring tool is still not widely used. Although there are now commercially available kits, there are limited data on biological guidance values for all but a few substances for breath monitoring. The study investigated the possibility of using an indirect breath sampler to measure the levels of nitrous oxide in the exhaled breath of midwives at a midpoint during their shift. Levels of nitrous oxide in the exhaled breath were measured at (0–727 ppm) with a mean level of 64 ppm. The correlation between the established personal environmental monitoring and exhaled breath monitoring was generally poor as was the correlation between duration of nitrous oxide exposure and levels in the exhaled breath. Clearly the use of exhaled breath as a tool for biological monitoring is more appropriate than other invasive procedures. The breath sampler used has been a readily acceptable tool for occupational hygiene monitoring in a busy hospital ward.

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References

  • Baird PA . Occupational exposure to nitrous oxide — not a laughing matter, N Engl J Med (1992) 327 (14): 1026–1027

    Article  CAS  Google Scholar 

  • Dyne D Cocker J Wilson HK . A Novel device for capturing breath samples for solvent analysis, Sci Total Environ (1997) 199: 83–89

    Article  CAS  Google Scholar 

  • Erikson A Kallen B . Survey of infants born in 1973 or 1975 to Swedish women working in operating rooms during their pregnancies, Anaesth Analg (1979) 58: 302

    Google Scholar 

  • Erikson A Kallen B . Hospitalisation for miscarriage and delivery room outcome among Swedish nurses working in operating rooms 1973–1978, Anaesth Analg (1985) 64: 981

    Google Scholar 

  • Guirguis SS Pelmear PL Roy ML Wong L . Health effects associated with exposure to anaesthetic gases in Ontario hospital personnel, Br J Occup Med (1990) 47 7 490–497

    CAS  Google Scholar 

  • Harrington JM . The health of Anaesthetists, Anaesthesia (1987) 42: 131–132

    Article  CAS  Google Scholar 

  • Hemminki K Kyyronen P Lindbohm ML . Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytotoxic drugs and other potential hazards in hospital based on registered information of outcome, J Epidemiol Community Health (1985) 39: 141

    Article  CAS  Google Scholar 

  • Henderson KA Matthews IP . An environmental survey of compliance with Occupational Exposure Standards (OES) for anaesthetic gases, Anaesthesia (1999) 54: 941–947

    Article  CAS  Google Scholar 

  • Kugel G Letelier C Attallah H Zive M . Chronic low level nitrous oxide exposure and infertility, J Dent Res (1989) 68: 313

    Google Scholar 

  • Markes International. Bio VOC Breath Sampler Guidance Sheet (August 2000)

  • Mitsui T Kondo T . Vegetables, high nitrate foods, increase breath nitrous oxide, Digest Dis Sci (1999) 44 (6): 1216–1219

    Article  CAS  Google Scholar 

  • Mitsui T Kato N Shimaoka K Miyamura M . Effect of aging on the concentrations of nitrous oxide in exhaled air, Sci Total Environ (1997) 208: 1–2, 133–1337

    Article  CAS  Google Scholar 

  • Monson RR . Occupation and reproduction, Occupational Epidemiology. CRC Press, Boca Raton (1990) 188

    Google Scholar 

  • Rowland AS Baird DD Weinberg CR Shore DL Shy CM Wilcox JA . Reduced fertility in women employed as dental assistants exposed to high levels of nitrous oxide, N Engl J Med (1992) 327 (14): 993–997

    Article  CAS  Google Scholar 

  • Spence AA . Environmental pollution by inhalation anaesthetics, Br J Anaesth (1987) 59: 93–103

    Google Scholar 

  • Spence AA Wall RA Nunn JF . Environmental safety of the anaesthetist, Gen Anaesth. 5th edn. Butterworth, London (1989) 595–608

    Google Scholar 

  • Tannenbaum TN Goldberg RJ . Exposure to anaesthetic gases and reproductive outcome, J Occup Med (1987) 9: 659–668

    Google Scholar 

  • Wallace L Buckley T Pellizzari E Gordon S . Breath measurements as volatile organic compound biomarkers, Environ Health Perspect (1996) 104: 861–969

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wilson HR . Breath analysis: physiological basis and sampling techniques, Scand J Work Environ Health (1986) 12: 174–192

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors express their thanks to the midwives who participated in this study, to Markes International which supplied the monitoring equipment and to H.S.L. who performed the analysis.

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Correspondence to I P MATTHEWS.

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HENDERSON, K., MATTHEWS, I. Biological monitoring of midwives' exposure to N2O using the Bio-VOC breath sampler. J Expo Sci Environ Epidemiol 12, 309–312 (2002). https://doi.org/10.1038/sj.jea.7500231

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