Abstract
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml−1, and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml−1, respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
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References
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Acknowledgements
This work was supported by the Pediatric Pharmacology Research Unit Network. Dr Cohen-Wolkowiez received support from the Lenox Baker fellowship and is the Lenox Baker Fellow. Dr Smith received support from T32 (HD-043728-01A2). Dr Benjamin received support from K23 (HD-044799-01) and 5U10 HD045962-03. Dr Wade received support from the Pediatric Pharmacology Research Unit (U01 HD037255-06). The assay of daptomycin concentrations was performed by Cubist Pharmaceuticals. We thank Dr Gordon Worley and the board of directors at the Lenox Baker Children's Hospital for their support during this project. There is no statistical support for this article.
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Cohen-Wolkowiez, M., Smith, P., Benjamin, D. et al. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol 28, 233–234 (2008). https://doi.org/10.1038/sj.jp.7211898
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DOI: https://doi.org/10.1038/sj.jp.7211898
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