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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Congenital disorders of glycosylation type Ia as a cause of mirror syndrome

Journal of Perinatology volume 27, pages 802–804 (2007)Cite this article

Abstract

Mirror syndrome (that is fetal hydrops with subsequent edema in the pregnant woman) is a rare condition. Early diagnosis is warranted, as maternal and fetal morbidity and mortality is increased if not diagnosed and treated properly. In most cases, the underlying cause remains unclear. We report a woman who has had two pregnancies complicated by mirror syndrome. Congenital disorder of glycosylation type Ia (CDG-Ia) was identified as the underlying fetal disease in both cases.

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References

  1. Abrams ME, Meredith KS, Kinnard P, Clark R . Hydrops Fetalis: a retrospective review of cases reported to a large national database and identification of risk factors associated with death. Pediatrics 2007; 120: 84–89.

    Article  Google Scholar 

  2. Goeden AM, Worthington D . Spontaneous resolution of mirror syndrome. Obstet Gynecol 2005; 106: 1183–1186.

    Article  Google Scholar 

  3. Stepan H, Faber R . Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops. NEJM 2006; 354: 1857–1858.

    Article  CAS  Google Scholar 

  4. Rana S, Venkatesha S, DePaepe M, Chien EK, Paglia M, Karamanchi SA . Cytomegalovirus-induced mirror syndrome associated with elevated levels of angiogenic factors. Obstet Gynecol 2007; 109: 549–552.

    Article  CAS  Google Scholar 

  5. Van Selm M, Kanhai HHH, Gravenhorst JB . Maternal hydrops syndrome: a review. Obstet Gynecol Surv 1991; 46: 785–788.

    Article  CAS  Google Scholar 

  6. Vidaeff AC, Pschirrer ER, Mastrobattista JM, Gilstrap LC, Ramin SM . Mirror syndrome. A case report. J Reprod Med 2002; 47: 770–774.

    PubMed  Google Scholar 

  7. Marquardt T, Denecke J . Congenital disorders of glycosylation: review of their molecular bases, clinical presentations and specific therapies. Eur J Pediatr 2003; 162: 359–379.

    CAS  PubMed  Google Scholar 

  8. De Lonlay P, Seta N, Barrot S, Chabrol B, Drouin V, Gabriel BM et al. A broad spectrum of clinical presentations in congenital disorders of glycosylation I: a series of 26 cases. J Med Genet 2001; 38: 14–19.

    Article  CAS  Google Scholar 

  9. Midgley DY, Harding K . The mirror syndrome. Eur J Obstet Gynecol Reprod Biol 2000; 88: 201–202.

    Article  CAS  Google Scholar 

  10. Pirhonen JP, Hartgill TW . Spontaneous reversal of mirror syndrome in a twin pregnancy after a single fetal death. Eur J Obstet Gynecol Reprod Biol 2004; 116: 106–107.

    Article  Google Scholar 

  11. Matthijs G, Schollen E, Bjursell C, Erlandson A, Freeze H, Imtiaz F et al. Mutations in PMM2 that cause congenital disorders of glycosylation, Type Ia (CDG-Ia). Human Mutation 2000; 16: 386–394.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics and Neonatology, University Children's Hospital, Homburg/Saar, Germany

    D Wurm, G Löffler & L Gortner

  2. Department of Pediatric Cardiology, University Children's Hospital, Homburg/Saar, Germany

    A Lindinger

Authors
  1. D Wurm
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  2. G Löffler
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  3. A Lindinger
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  4. L Gortner
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Correspondence to D Wurm.

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Wurm, D., Löffler, G., Lindinger, A. et al. Congenital disorders of glycosylation type Ia as a cause of mirror syndrome. J Perinatol 27, 802–804 (2007). https://doi.org/10.1038/sj.jp.7211847

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  • DOI: https://doi.org/10.1038/sj.jp.7211847

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