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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

An unusual case of retinopathy of prematurity

Journal of Perinatology volume 27, pages 315–316 (2007)Cite this article

Abstract

Aims:

Stage 3 retinopathy of prematurity (ROP) usually develops in the very small babies. An infant born at 30 (2) weeks' gestation and of birth weight 2102 g was found to have stage 3 ROP bilaterally. The unusual severity of the disease in a child of birth weight >2000 g prompted further investigation. The aim was to look for any genetic causes for ROP.

Methods:

Chromosomal analysis followed by vasculoendothelial growth factor (VEGF) analysis.

Results:

Unbalanced translocation 18p (monosomy) and 6p (trisomy). Overexpression of VEGF.

Conclusions:

Overexpression of VEGF contributed to the unusual severity of ROP in this relatively large baby.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, Cheshire, UK

    K Mandal

  2. Departments of Genetics and Perinatology, Division of Perinatal and Reproductive Medicine, University of Liverpool, Liverpool Women's Hospital, Liverpool, Cheshire, UK

    J A Drury

  3. Department of Ophthalmology, Walton Daycase and Outpatient Centre, Liverpool, Cheshire, UK

    D I Clark

Authors
  1. K Mandal
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  2. J A Drury
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  3. D I Clark
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Corresponding author

Correspondence to K Mandal.

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Mandal, K., Drury, J. & Clark, D. An unusual case of retinopathy of prematurity. J Perinatol 27, 315–316 (2007). https://doi.org/10.1038/sj.jp.7211674

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  • DOI: https://doi.org/10.1038/sj.jp.7211674

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