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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Transplacental isopropanol exposure: case report and review of metabolic principles

Journal of Perinatology volume 27, pages 183–185 (2007)Cite this article

Abstract

Isopropanol, a known central nervous system depressant has been reported to cause toxicity via multiple routes including ingestion, inhalation and dermal exposure. We present a case of transplacental isopropanol exposure in a neonate. A woman reported polysubstance abuse in the 1 to 2 days before precipitously delivering a newborn infant. The neonate developed hypotension, hypotonia and seizure activity within the first few hours of life. Blood samples from the infant revealed toxic levels of isopropanol. Similar symptoms have been reported in infants with isopropanol toxicity from other routes of exposure.

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Authors and Affiliations

  1. Division of General Pediatrics, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    J N Wood & J Carney

  2. Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    K Szczepanski & H Hurt

  3. Division of Pediatric Emergency Medicine, Department of Pediatrics, Section of Medical Toxicology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    D P Calello

Authors
  1. J N Wood
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  2. J Carney
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  3. K Szczepanski
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  4. D P Calello
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  5. H Hurt
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Correspondence to J N Wood.

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Wood, J., Carney, J., Szczepanski, K. et al. Transplacental isopropanol exposure: case report and review of metabolic principles. J Perinatol 27, 183–185 (2007). https://doi.org/10.1038/sj.jp.7211646

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  • DOI: https://doi.org/10.1038/sj.jp.7211646

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