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Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

Journal of Perinatology volume 24, pages 626–630 (2004)Cite this article

Abstract

OBJECTIVE: To compare immediate changes in lung compliance following the administration of two commercially available natural surfactants.

METHOD: We conducted a prospective, randomized study of 40 preterm infants with respiratory distress syndrome requiring surfactant. Infants received either Infasurf® or Survanta®. The primary outcome measure was the change in compliance assessed by bedside pulmonary monitoring.

RESULTS: There were no significant changes in dynamic lung compliance within or between the two groups 1 hour after surfactant administration. However, infants given Survanta required more doses per patient (4 vs 2, p=0.05) and were more likely to require >2 doses (57 vs 26%, p=0.05). Infants requiring >1 dose of surfactant had a greater change in airway pressure and improved oxygenation just before the second dose when treated with Infasurf.

CONCLUSIONS: We found no significant difference in acute changes in lung compliance. However, treatment with Infasurf seems to be more long lasting than Survanta.

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Authors and Affiliations

  1. Department of Pediatrics and Communicable Diseases, University of Michigan, MI, USA

    Mohammad A Attar MD & Steven M Donn MD

  2. Department of Critical Care Support Services, University of Michigan Health System, MI, USA

    Michael A Becker RRT & Ronald E Dechert RRT, Dr. PH

Authors
  1. Mohammad A Attar MD
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  2. Michael A Becker RRT
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  3. Ronald E Dechert RRT, Dr. PH
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  4. Steven M Donn MD
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Attar, M., Becker, M., Dechert, R. et al. Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial. J Perinatol 24, 626–630 (2004). https://doi.org/10.1038/sj.jp.7211160

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