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Feasibility of Nitric Oxide Administration by Oxygen Hood in Neonatal Pulmonary Hypertension

Journal of Perinatology volume 22, pages 50–56 (2002)Cite this article

Abstract

OBJECTIVE: To test the hemodynamic efficacy and feasibility of nitric oxide (NO) administration by oxygen hood in neonatal pulmonary hypertension.

STUDY DESIGN: A double-hood apparatus was used in which a combination of NO, O2, and N2 was introduced into the inner hood and suctioned from the outer hood. Chronically instrumented non-intubated piglets were exposed to 10% O2 (hypoxia; n=8) or group B streptococci infusion (GBS; n=5) to produce pulmonary hypertension and were then exposed to 20 ppm NO.

RESULTS: NO decreased (>50%) pulmonary artery pressure and vascular resistance in both hypoxia- and GBS-induced pulmonary hypertension, with minimal effects on systemic arterial pressure and cardiac output. NO administration could be performed without detectable environmental leakage.

CONCLUSION: Hood NO administration is feasible and shows hemodynamic efficacy in neonatal piglets with pulmonary hypertension.

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Acknowledgements

We acknowledge the assistance of Tom Gadilhe RRT for his technical assistance in this project.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA

    Namasivayam Ambalavanan MD, Elaine St. John MD, Waldemar A Carlo MD, Arlene Bulger BS & Joseph B Philips III MD

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  1. Namasivayam Ambalavanan MD
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  2. Elaine St. John MD
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  3. Waldemar A Carlo MD
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  4. Arlene Bulger BS
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  5. Joseph B Philips III MD
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Ambalavanan, N., St. John, E., Carlo, W. et al. Feasibility of Nitric Oxide Administration by Oxygen Hood in Neonatal Pulmonary Hypertension. J Perinatol 22, 50–56 (2002). https://doi.org/10.1038/sj.jp.7210652

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