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Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma

British Journal of Cancer volume 82, pages 1646–1649 (2000)Cite this article

Abstract

A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer. © 2000 Cancer Research Campaign

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References

  • Bartsch H, Malaville C, Lowenfels AB, Maisonneuve P, Hautefeuille A and Boyle P (1998) Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group. Eur J Cancer Prev 7: 215–233

    Article  CAS  Google Scholar 

  • Flanders TY and Foulkes WD (1996) Pancreatic adenocarcinoma: epidemiology and genetics. J Med Genet 33: 889–898

    Article  CAS  Google Scholar 

  • Foulkes WD, Brunet JS, Sieh W, Black MJ, Shenouda G and Narod SA (1996) Familial risks of squamous cell carcinoma of the head and neck: restrospective case–control study. Br Med J 313: 716–721

    Article  CAS  Google Scholar 

  • Hirvonen A (1995) Genetic factors in individual responses to environmental exposures. J Occup Environ Med 37: 37–43

    Article  CAS  Google Scholar 

  • Howe GR and Burch JD (1996) Nutrition and pancreatic cancer. Cancer Causes Control 7: 69–82

    Article  CAS  Google Scholar 

  • Lee HC, Yoon YB and Kim CY (1997) Association between genetic polymorphisms of the cytochrome P450 (1A1, 2D6, 2E1) and the susceptibility to pancreatic cancer. Korean J Intern Med 12: 128–136

    Article  CAS  Google Scholar 

  • Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B and Taylor JB (1994) Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300: 271–276

    Article  CAS  Google Scholar 

  • Persson I, Johansson I and Ingelman-Sundberg M (1997) In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem Biophys Res Commun 231: 227–230

    Article  CAS  Google Scholar 

  • Rebbeck TR (1997) Molecular epidemiology of human glutathione S-transferase genotypes GST-M1 and GST-T1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev 6: 733–743

    CAS  PubMed  Google Scholar 

  • Rebbeck TR, Rosvold EA, Duggan, DJ Zhang J and Buetow KH (1994) Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer. Cancer Epidemiol, Biomarkers Prev 3: 511–514

    CAS  Google Scholar 

  • Xu X, Kelsey KT, Wiencke JK, Wain JC and Christiani DC (1996) Cytochrome P450 CYP1A1 Msp1 polymorphisms and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 5: 687–692

    CAS  PubMed  Google Scholar 

  • Zhang ZY, Fasco MJ, Huang L, Guengerich F and Kaminsky LS (1996) Characterization of purified human recombinant cytochrome P450A1-Ile462 and -Val462: assessment of a role for the rate allele in carcinogenesis. Canc Res 56: 3926–3933

    CAS  Google Scholar 

  • Zhong S, Wyllie AH, Barnes D, Wolf CR and Spurr NK (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14: 1821–1824

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Toronto, M5G 1N8, Canada

    G Liu, D Vesprini & S A Narod

  2. Centre de Recherche, Pavillon Hotel Dieu, CHUM, Montreal, H2W 1T8, Quebec, Canada

    P Ghadirian & A-J Paradis

  3. Department of Medicine, Montreal General Hospital Research Institute, McGill University, Montreal, H3G 1A4, Quebec, Canada

    N Hamel & W D Foulkes

  4. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, M5G 1X5, Canada

    G Lal & S Gallinger

Authors
  1. G Liu
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  2. P Ghadirian
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  3. D Vesprini
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  4. N Hamel
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  5. A-J Paradis
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  6. G Lal
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  7. S Gallinger
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  8. S A Narod
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  9. W D Foulkes
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Liu, G., Ghadirian, P., Vesprini, D. et al. Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma. Br J Cancer 82, 1646–1649 (2000). https://doi.org/10.1054/bjoc.2000.1221

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  • DOI: https://doi.org/10.1054/bjoc.2000.1221

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