Summary
Bcl10 is a recently identified gene reported to be involved commonly in human malignancy (Willis et al (1999) Cell 96: 1–20). To investigate whether it is frequently mutated in colorectal cancer we have analysed a series of 132 colorectal cancers and eight colorectal cancer cell lines for mutations in Bcl10. One feature of the Bcl10 gene is that it harbours two polyadenine tracts. These repeating elements in genes can be prone to a high rate of mutation if there is defective mismatch repair. To examine the possibility that Bcl10 may be preferentially mutated in mismatch repair-deficient cancers, 49 of the tumours and cell lines were known to be replication error (RER)-positive and, of these, ten were from individuals harbouring germline mutations in hMLH1 or hMSH2. No pathogenic mutations were detected in the tumours and only one mutation was found in the colorectal cancer cell lines. These results indicate that Bcl10 is unlikely to be involved in the pathways of colorectal carcinogenesis.
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16 November 2011
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References
Fearon, E. R. & Vogelstein, B. (1990). A genetic model for colorectal tumourigenesis. Cell 61: 759–767.
Ganguly, A., Rock, M. J. & Prockop, D. J. (1993). Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes. Proc Natl Acad Sci USA 90: 10325–10329.
Ilyas, M. & Tomlinson, I. P. M. (1996). Genetic pathways in colorectal cancer. Histopathology 28: 389–399.
Parsons, R., Myeroff, L. L., Liu, B., Willson, J. K., Markowitz, S. D., Kinzler, K. W. & Vogelstein, B. (1995). Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 55: 5548–5550.
Willis, T. G., Jadayel, D. A., Du, M. Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Karren, L., Majekodumi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P. G. & Dyer, M. J. S. (1999). Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96: 1–20.
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Stone, J., Rowan, A., Tomlinson, I. et al. Mutations in Bcl10 are very rare in colorectal cancer. Br J Cancer 80, 1569–1570 (1999). https://doi.org/10.1038/sj.bjc.6690562
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DOI: https://doi.org/10.1038/sj.bjc.6690562
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