Summary
The sera from patients with nasopharyngeal carcinoma (n = 30), oral carcinoma (n = 22) and laryngeal carcinoma (n = 22) was extracted before treatment. The concentration of circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) was measured by enzyme-linked immunoassay and compared with those from normal subjects (n = 20). The concentration of circulating ICAM-1, E-selectin and VCAM-1 was significantly increased in nasopharyngeal carcinoma. Correspondingly, VCAM-1 and E-selectin were significantly increased in laryngeal carcinoma, whereas only E-selectin was elevated in oral carcinoma. The concentrations of these adhesion molecules did not significantly differ with respect to the early and late stages of these carcinomas. Elevated levels of soluble adhesion molecules in the sera of cancer patients at three different head and neck regions, although appearing to be implicated in these tumour formations, may be unrelated to tumour progression.
Similar content being viewed by others
Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Azuma, A., Yagita, H., Okumura, K. & Niitani, H. (1992). Induction of intercellular adhesion molecule 1 on small cell lung carcinoma cell lines by γ-interferon enhances spontaneous and bispecific anti-CD 3 × antitumor antibody-directed lymphokine-activated killer cell cytotoxicity. Cancer Res 52: 4890–4894.
Banks, R. E., Gearing, A. J. H., Hemingway, I. K., Norfolk, D. R., Perren, T. J. & Selby, P. J. (1993). Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies. Br J Cancer 68: 122–124.
Becker, J. C., Dummer, R., Hartmann, A. A., Berg, G. & Schmidt, R. E. (1991). Shedding of ICAM-1 from human melanoma cell lines induced by IFNγ and tumor necrosis factor α: functional consequences on cell-mediated cytotoxicity. J Immunol 147: 4398–4401.
Bevilacqua, M. P. & Nelson, R. M. (1993). Selectins. J Clin Invest 91: 379–387.
Birdsall, H. H., Lane, C., Ramser, M. N. & Anderson, D. C. (1992). Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adhesion. J Immunol 148: 2717–2723.
Gearing, A. J. H. & Newman, W. (1993). Circulating adhesion molecules in disease. Immunol Today 14: 506–512.
Giavazzi, R., Chirivi, R. G. S., Garofalo, A., Rambaldi, A., Hemingway, I. K., Pigott, R. & Gearing, A. J. H. (1992). Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice. Cancer Res 52: 2628–2630.
Harning, R., Mainolfi, E., Bystryn, J. C., Henn, M., Merluzzi, V. J. & Rothlein, R. (1991). Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma. Cancer Res 51: 5003–5005.
Hsu, M. M., Ko, J. Y. & Chang, Y. L. (1991). Elevated levels of soluble interleukine-2 receptor, and tumor necrosis factor in naspharygeal carcinoma. Arch Otolaryngol Head Neck Surg 117: 1257–1259.
Kageshita, Y., Yoshii, A., Kimura, T. & Ono, T. (1992). Analysis of expression and soluble form of intercellular adhesion molecule-1 in malignant melanoma. J Dermatol 19: 836–840.
Koch, A. E., Burrows, J. C., Haines, G. K., Calos, T. M., Harlan, J. M. & Leibovich, S. J. (1991). Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab Invest 64: 313–320.
Kuo, W. R., Yu, H. S., Chang, K. L., Juan, K. H., Jan, Y. S. & Yu, C. L. (1994). Increased production of tumor necrosis factor-α and release of soluble CD 4 and CD 8 molecules, but decreased responsiveness to phytohemagglutinin in patients with nasopharyngeal carcinoma. J Formos Med Assoc 93: 569–575.
Kuzu, I., Bicknell, R., Fletcher, C. D. & Gatter, K. C. (1993). Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors. Lab Invest 69: 322–328.
Lauri, D., Needham, L. A., Martin-Padura, I. & Dejana, E. (1991). Tumor cell adhesion to endothelial cells: endothelial leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells. J Natl Cancer Inst 83: 1321–1324.
Maio, M., Gulwani, B., Langer, J. A., Kerbel, R. S., Duigou, G. J., Fisher, P. B. & Ferrone, S. (1989). Modulation by interferons of HLA antigen, high-molecular-weight melanoma-associated antigen, and intercellular adhesion molecule-1 expression by cultured melanoma cells with different metastatic potential. Cancer Res 49: 2980–2987.
McCarthy, J. B., Skubitz, A. P. N., Iida, J., Mooradian, D. L., Wilke, M. S. & Furcht, L. T. (1991). Tumor cell adhesive mechanisms and their relationship to metastasis. Semin Cancer Biol 2: 155–167.
Natali, P., Nicotra, M. R., Cavaliere, E., Bigotti, A., Romano, G., Temponi, M. & Ferrone, S. (1990). Differential expression of intercellular adhesion molecule-1 in primary and metastatic melanoma lesion. Cancer Res 50: 1271–1278.
Pigott, R., Dillon, L. P., Hemingway, I. H. & Gearing, A. J. H. (1992). Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated endothelial cells. Biochem Biophys Res Commun 187: 584–589.
Pizzolo, G., Vinante, F., Nadali, G., Ricetti, M. M., Morosato, L., Marrocchella, R. & Vincenzi, C. (1993). ICAM-1 tissue over-expression associated with increased serum levels of its soluble form in Hodgkin’s disease. Br J Haematol 84: 161–162.
Price, J. T., Bonovich, M. T. & Kohn, E. C. (1997). The biochemistry of cancer dissemination. Crit Rev Biochem Mol Biol 32: 175–253.
Rice, G. E. & Bevilacqua, M. P. (1989). An inducible endothelial cell surface glycoprotein mediates adhesion. Science 246: 1303–1306.
Rice, G. E., Munro, J. M., Corless, C. & Bevilacqua, M. P. (1991). Vascular and nonvascular expression of INCAM-110. Am J Pathol 138: 385–393.
Roitt, I., Brostoff, J. & Male, D. (1993). Cell migration and inflammation. In Immunology, pp. 13.1–13.8, Mosby: London
Rothlein, R., Dustin, M. L., Marlin, S. D. & Springer, T. A. (1986). A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137: 1270–1274.
Rothlein, R., Mainolf, E. A., Czajkowski, M. & Marlin, S. D. (1991). A form of circulating ICAM-1 in human serum. J Immunol 147: 3788–3793.
Seth, R., Raymond, F. D. & Mukgoba, M. W. (1991). Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 338: 83–84.
Smith, M. E. F., ThoSmith, M. E. F. & Thomas, J. A. (1990). Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-1 in normal tissue. J Clin Pathol 43: 898–900.
Tomita, Y., Nishiyama, T., Watanabe, H., Fujiwara, M. & Sato, S. (1990). Expression of intercellular adhesion molecule-1 (ICAM-1) on renal cell cancer: possible significance in host immune response. Int J Cancer 46: 1002–1006.
Tsuhsaki, M., Imai, K., Hirata, H., Hanzawa, Y., Masuya, J., Nakano, T. & Sugiyama, T. (1991). Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol 85: 3–8.
Vanky, F., Wang, P., Patarroyo, M. & Klein, E. (1990). Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on human tumor cells is required for their interaction with autologous lymphocytes in vitro. Cancer Immunol Immunother 31: 19–27.
Wenzel, C. T., Scher, R. L. & Richtsmeier, W. J. (1995). Adhesion of head and neck squamous cell carcinoma to endothelial cells. Arch Otolaryngol Head Neck Surg 121: 1279–1286.
Yamanoto, T., Yoneda, K., Ueta, E. & Osaki, T. (1994). Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders. Oral Surg Oral Med Oral Pathol 78: 727–735.
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Liu, CM., Sheen, TS., Ko, JY. et al. Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer. Br J Cancer 79, 360–362 (1999). https://doi.org/10.1038/sj.bjc.6690057
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bjc.6690057
Keywords
This article is cited by
-
Down regulation of endothelial adhesion molecules in node positive breast cancer: Possible failure of host defence mechanism
Pathology & Oncology Research (2002)
-
Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis
Oncogene (2001)
-
Clinical implications of biomarkers in head and neck cancer
Current Oncology Reports (1999)