Abstract
Objective To establish the efficacy and safety of 25% minocycline slow-release ointment when used intermittently as an adjunct to subgingival debridement in non-surgical treatment of routine chronic adult periodontitis over a prolonged period.
Design Multicentre double-blind randomised controlled trial at six university centres from 1993–1999.
Intervention Adults (104 in number) of 35–64 years of age, with at least one pocket ⩾5 mm with attachment loss ⩾3 mm, radiographic evidence of alveolar bone loss in at least one site per quadrant, gingival index ⩾1 and plaque index ⩾2, were randomised to treatment with minocycline or a vehicle control. Patients using anti-inflammatory drugs or mouthwash and receiving antibiotics in the previous 3 months were excluded.
Outcome measures Probing depth, probing attachment level, sulcus bleeding index, gingival index, plaque index, % of sites improving >2 mm and microbial evaluation.
Results Eleven cases were excluded. Results showed significant reductions in micro-organisms measured, mean probing depth, bleeding index and gains in attachment. No hypersensitivity was reported, and 15% of the minocycline group and 27% of control group reported minor adverse symptoms.
Conclusion Repeated administration of minocycline ointment as an adjunct to scaling and polishing resulted in statistically significant improvements (over 15 months) in periodontal clinical status, and significant reductions in periodonto-pathogens for both therapies
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van Steenberghe D, Rosling B, Soder P-O, van der Velden U, Timmerman MFT, McCarthy EF, et al. A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis. J Periodont 1999; 70:657–667
Address for reprints: Dr D van Steenberghe, Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer, B-3000 Leuven, Belgium.
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Niederman, R. Minocycline gel gives adjunctive improvement to scale and polish. Evid Based Dent 2, 65 (2000). https://doi.org/10.1038/sj.ebd.6400048
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DOI: https://doi.org/10.1038/sj.ebd.6400048