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Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene

Genes & Immunity volume 5, pages 310–312 (2004)Cite this article

Abstract

T-cell-specific adapter protein (TSAd) involved in the negative control of T-cell activation is encoded by the SH2D2A gene. Our recent studies indicate that homozygosity for short (ie GA13 and GA16) alleles of the SH2D2A gene promoter is associated with development of multiple sclerosis. To study whether the same SH2D2A promoter polymorphism also contributes to the genetic susceptibility to develop juvenile rheumatoid arthritis (JRA), we examined 210 JRA patients and 558 healthy unrelated controls from Norway. The frequency of the short allele GA13 was increased among the JRA patients compared to control (0.098 vs 0.05; Pn=8=0.042). There was a significant increased frequency of HLA-DRB1*08-positive patients carrying two copies of ‘short’ alleles GA13 and/or GA16 compared to healthy controls (16% vs 6%; Pn=4=0.016). Our data indicate that the ‘short’ alleles of the SH2D2A promoter could contribute to the genetic susceptibility to JRA.

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Acknowledgements

I Knutson is thanked for technical support. Financial support has been given from the Norwegian Women Public Health Organization, Norwegian Research Council, Grethe Harbitz Legacy, a grant from MSD, from Schering-Plough, from Wyeth, and from Abbott Immunology.

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Authors and Affiliations

  1. Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway

    A Smerdel, A R Lorentzen & E Thorsby

  2. Department of Anatomy, Institute of Basal Medical Sciences, University of Oslo, Norway

    K-Z Dai & A Spurkland

  3. The Department of Rheumatology, Rikshospitalet University Hospital, Oslo, Norway

    B Flatø & Ø Førre

  4. Institute of Rheumatology, Warsaw, Poland

    S Maslinski

Authors
  1. A Smerdel
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  2. K-Z Dai
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  6. E Thorsby
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  8. A Spurkland
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Correspondence to A Smerdel.

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Smerdel, A., Dai, KZ., Lorentzen, A. et al. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. Genes Immun 5, 310–312 (2004). https://doi.org/10.1038/sj.gene.6364093

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  • DOI: https://doi.org/10.1038/sj.gene.6364093

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