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Linkage analysis suggests a region of importance for multiple sclerosis in 3p14–13

Genes & Immunity volume 2, pages 451–454 (2001)Cite this article

Abstract

Four genomic screens for linkage in multiple sclerosis (MS) have been reported. They confirmed the established role of the human leucocyte antigen (HLA) complex genes in MS and, in addition, suggested the importance of a few other chromosomal segments. Here we report evidence for the importance of 3p14–13 region identified by suggestive linkage in genomic screens from Canada and the United Kingdom. When studying 146 Nordic MS multiplex families, mostly affected sib-pairs, with eight microsatellite markers, spanning a 36-cM region, we observed a two-point non-parametric linkage (NPL) score of 2.39 (P = 0.007) by the GENEHUNTER package for marker D3S1285 and a multipoint NPL score of 1.20 in the same region. Association studies in Swedish MS patients revealed modest allelic associations of uncertain significance not supported by transmission analysis. Analysis of the trinucleotide repeat sequence of the SCA7 gene in Swedish index cases did not reveal expansions. We conclude that support was obtained for the location of a gene or genes with importance for MS susceptibility in 3p14–13 region.

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Authors and Affiliations

  1. Department of Neurology, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden

    Y Dai, C Xu, S Fredrikson & J Hillert

  2. Department of Clinical Genetics, Umea University, Umea, Sweden

    M Holmberg

  3. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

    A Oturai, LP Ryder & A Svejgaard

  4. Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

    A Oturai & PS Sorensen

  5. Department of Neurology, Lund University Hospital, Lund, Sweden

    M Sandberg-Wollheim

  6. Turku Immunology Centre and Department of Virology, University of Turku, Finland

    M Laaksonen

  7. Institute of transplantation immunology, Rikshospitalet, Oslo, Norway

    A Spurkland

  8. Department of Neurology, Haukelands Hospital, University of Bergen, Norway

    KM Myhr

Authors
  1. Y Dai
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  2. C Xu
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  3. M Holmberg
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  4. A Oturai
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  5. S Fredrikson
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  6. M Sandberg-Wollheim
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  7. M Laaksonen
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  8. A Spurkland
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  9. KM Myhr
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  10. LP Ryder
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  11. PS Sorensen
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  12. A Svejgaard
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  13. J Hillert
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Corresponding author

Correspondence to J Hillert.

Additional information

This study was supported by the Swedish Medical Research Council (project numbers: 11023 and 11220), the European Commission (project number CT97–2422), the Society for the Neurologically Disabled, the Sigurd and Elsa Goljes Minne foundation, the Karolinska Institute, the Magn Bergvalls foundation, the Ake Wiberg foundation, the Bibbi and Nils Jensens Foundation and the Marcus Borgströms foundation. We thank the Danish Multiple Sclerosis Society for financial support.

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Dai, Y., Xu, C., Holmberg, M. et al. Linkage analysis suggests a region of importance for multiple sclerosis in 3p14–13. Genes Immun 2, 451–454 (2001). https://doi.org/10.1038/sj.gene.6363805

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  • DOI: https://doi.org/10.1038/sj.gene.6363805

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